By mimicking the natural cell membrane consisting of a phospholipid bilayer, biocompatible and high performance medical device coatings can be prepared. In nature, the cell membrane, more specifically the phospholipid bilayer, serves as a universal interface between distinct chemical environments.
‘a 5 nanometer coating that mimics the outside of a cel’
- Improve wetting
- Tailor lubricity
- Custom chem.
- No toxity
- ISO 10993-5
- No clotting
- Dip coating
- O2 plasma
- Low cost
- Non-animal based
A major global challenge in healthcare is medical device complications, especially contaminated devices, such as catheters, one of the leading causes of Healthcare Associated Infections (HAIs).
It has been estimated that around 6% of HAI cases result in death. According to a GE whitepaper, every year in the US alone, HAIs affect about 1.7 million people at a cost of more than $35 billion, some estimates reaching $88 billion spent annually on these debilitating and often fatal infections. HAIs are responsible for prolonging hospital stays by approximately 16 million days and causing nearly 100,000 deaths annually. The situation is similar in the European Union, where yearly over 4 million patients acquire a HAI. These infections are estimated to contribute to roughly 110,000 deaths, along with significant cost to health systems. The direct costs were estimated by the World Health Organisation to total at least EUR 7 Billion, every year. In the case of critically ill patients, the preponderant number of infections are associated with medical devices: 95% of cases of urinary tract infection are catheter related, 87% of cases of bloodstream infection originate from an indwelling vascular catheter, and 86% of cases of pneumonia are associated with mechanical ventilation.
LipoCoat© coatings are aimed at reducing HAI cases and improving medical device comfort and performance in a drug-less, no-active fashion using a bio-inspired mild solution.
R&D, especially in the areas of pharma and (stem) cell research require specific surface functionality for either cell culture or drug-screening analysis.
Nowadays, careful control of cell culture conditions in R&D is becoming ever more important. Especially in the stem cell field, there is a need to design tunable cell culture surfaces. For example, labs that routinely culture embryonic stem cells demand non-fouling and non-adsorbing surfaces to ensure proper cell growth.
LipoCoat © coatings offers the possibility of being engineered to display and include different proteins and other bio-actives in order to impart a specific bio-activity, rather than being a (bio)inert surface. For example, if you wanted to activate other cells such as stem cells or immune cells, detect certain proteins or to encourage tailored cell adhesion or even capture molecules LipoCoat© coatings can be used. Non-fouling and non-adherent are equally important for stem cell and drug screening applications. The technology enable the design and preparation of bio-active surfaces through supramolecular or chemical modification. Therefore low background, cell-compatible surfaces and, if so desired, spatiotemporal incorporation of biochemical cues are accessible, improving or enabling new types of analysis.
In industry, any wetted surface that is required to be clean of contaminants, requires specific surface functionality can be considered for LipoCoat© coatings.
These encompass industrial applications within drug manufacturing, food processing and water purification.
For example, in the dairy industry, filtration processes are often hampered by fouling and blockages of membranes. Given LipoCoat’s unique properties, proteins in milk cannot adhere to the surface of coated filtration devices preventing clogging and increasing production time. In addition, the production of high-value protein-based products would benefit from the use of LipoCoat during their production in order to minimize losses due to fouling. Equally important is the design of a water purification solution that enables the removal of small organic wastes such a drugs and hormones from waste water. LipoCoat technology could offer a platform solution to tailor membrane properties to enable such functionality.
Lipocoat: The Solution
The patented coating developed by LipoCoat tackles the aforementioned problems in an elegant way offering a solution to direct problems, as well as preventing the development of some of the potential issues.
Lipocoat: Latest news
The lates news about Lipocoat.
SIMPLE. EASY. SCALABLE.
Whilst the coating is manufactured from synthetic chemicals, the ultimate product completely mimics a biological product. The whole process is quick and efficient using LipoCoat’s Fast Amphiphile Solution Transfer (FAST) technology.
ADAPTABLE. CUSTOMISABLE. INNOVATIVE.
LipoCoat is highly adaptable to many uses due to its ‘toolbox’ technology whereby distinct properties can be customised. With a range of formulations, its hydrophilicity, stability and lubricity can be adjusted to complement the inherent anti-biofouling and anti-thrombogenic nature of the coating. An additional asset of LipoCoat, due to its dynamic, fluid nature is the ability to self-repair should scratches expose the medical device to the biological environment.
SAFE. NATURAL. ORGANIC.
A key advantage of LipoCoat is the fact that the coating is imitating the phospholipid bilayer that surrounds every cell in our body. Hence, it is highly biocompatible and should not elicit an inflammatory response. Even if the coating sheds from the medical device, it should be disposed of by the body as it would do naturally any dead or dying cell and no side-effects should occur.