Pipeline

Pipeline

LipoCoat Pipeline

LipoCoat contact lens products are aimed at improving comfort and safety properties of the contact lens materials by increasing surface wetting, increasing surface lubricity and reduce surface contamination by reducing deposits and bacterial build-up on the lens material. We develop surface coatings that can be adapted for use on rigid gas permeable contact lenses, soft contact lenses and can be provided as an additive to lens care solutions. Contact lens coating products are prepared for CE-clearance.

LipoCoat catheter products provide a passive and drug-less solution to reduce biofilm formation, improve blood compatibility and prevent tissue damage. LipoCoat coatings can be applied without the need for curing steps, polymerization or UV treatment. Process and thickness control is programmed into our molecular design. In addition, no harsh chemicals, pharmaceuticals or active compounds are processed into the final products. Catheter coating products for urology and cardiovascular catheters are in development.

The LipoCoat coating platform can be adapted to display a wide-range of bio-active compounds. These can provide additional surface properties to trigger specific biological processes in vivo or in vitro. Osseointegration improvement using LipoCoat coatings on orthopedic implants are under investigation.

Eye care: Contact lenses
Contact lenses are commonly used medical devices to manage refractive errors. It is estimated that approximately 150 million people wear contact lenses worldwide1. Several complications are associated with wearing contact lenses such as discomfort, eye infections, dry eyes and corneal neovascularization2.

LipoCoat contact lens products are aimed at improving comfort and safety properties of the contact lens materials by increasing surface wetting, increasing surface lubricity and reduce surface contamination by reducing deposits and bacterial build-up on the lens material. We develop surface coatings that can be adapted for use on rigid gas permeable contact lenses, soft contact lenses and can be provided as an additive to lens care solutions. Contact lens coating products are prepared for CE-clearance.

Eye care: Eye spray
To combat dry eyes, which are in most cases caused by a deficiency or instability of the lipid layer of the tear film, different eye spray technologies have been developed. Currently available lipid-based eye-sprays are based on the phospholipid soy-lecithin encapsulated within microscopic spherical liposomal vesicles. It has been shown that the use of liposomal eye spray significantly improves the thickness of the lipid layer and the tear film stability. Compared to aqueous artificial tear ocular lubricants, liposomal eye sprays focus more on symptom relief and require frequent application3.

LipoCoat’s proprietary coating platform provides the possibility of negating the negative properties of soy-lecithin such as the pungent smell, and markedly amplifying the positive effects. It is suggested that LipoCoat’s lipids could elicit an anti-inflammatory response, and that they can be combined with other beneficial compounds. Also, that they could be applied as a drug delivery system with the benefit of enabling a high degree of control4.

  1. Moreddu, R., Vigolo, D. & Yetisen, A. K. Contact Lens Technology: From Fundamentals to Applications. Adv. Healthc. Mater. 8, 1–24 (2019).
  2. Alipour, F., Khaheshi, S., Sleimanzadeh, M., Heidarzadeh, S. & Heydarzadeh, S. Contact-lens related Complications: A Review. J. Ophthalmic Vis. Res. 12, 270–274 (2017).
  3. Pult, H., Gill, F. & Riede-Pult, B. H. Effect of three different liposomal eye sprays on ocular comfort and tear film. Contact Lens Anterior Eye 35, 203–207 (2012).
  4. Garrigue, J., et al. Relevance of Lipid-Based Products in the Management of Dry Eye Disease. Journal of Ocular Pharmacology and TherapeuticsVol. 33, No. 9, 647-661 (2017).

Catheters
A global healthcare challenge are complications with medical devices. Especially contaminated device such as catheters, are one of the leading causes of Healthcare Associated Infections (HAIs)1. It has been estimated that around 6% of HAI cases result in death. Every year in the US alone, HAIs affect about 1.7 million people at a cost of more than $35 billion, some estimates reaching $88 billion spent annually on these debilitating and often fatal infections. HAIs are responsible for prolonging hospital stays by approximately 16 days on average and causing nearly 100,000 deaths annually. The situation is similar in the European Union, where yearly over 4 million patients acquire an HAI2. These infections are estimated to contribute to roughly 110,000 deaths, along with significant costs to healthcare systems. The direct costs were estimated by the World Health Organisation to total at least €7 Billion, every year. In the case of critically ill patients, the preponderant number of infections are associated with medical devices: 95% of cases of urinary tract infection are catheter related, 87% of cases of bloodstream infection originate from an indwelling vascular catheter, and 86% of cases of pneumonia are associated with mechanical ventilation3.

LipoCoat© coatings are aimed at reducing HAI cases and improving medical device comfort and performance in a drug-less, no-active fashion using a bio-inspired mild solution.

LipoCoat catheter products provide a passive and drug-less solution to reduce biofilm formation, improve blood compatibility and prevent tissue damage. LipoCoat coatings can be applied without the need for curing steps, polymerization or UV treatment. Process and thickness control is programmed into our molecular design. In addition, no harsh chemicals, pharmaceuticals or active compounds are processed into the final products. Catheter coating products for urology and cardiovascular catheters are in development.

  1. Haque, M., Sartelli, M., McKimm, J. & Bakar, M. A. Health care-associated infections – An overview. Infection and Drug Resistance vol. 11 2321–2333 (2018).
  2. European Centre for Disease Prevention and Control. Incidence and attributable mortality of healthcare-associated infections in intensive care units in Europe 2008-2012. Incidence and attributable mortality of healthcare-associated infections in intensive care units in Europe 2008-2012 (2018). doi:10.2900/118774.
  3. Guggenbichler, J. P., Assadian, O., Boeswald, M. & Kramer, A. Incidence and clinical implication of nosocomial infections associated with implantable biomaterials – catheters, ventilator-associated pneumonia, urinary tract infections. GMS Krankenhhyg. Interdiszip. 6, Doc18 (2011).

Drug discovery
R&D, especially in the areas of pharma and (stem) cell research require specific surface functionality for either cell culture or drug-screening analysis. Nowadays, careful control of cell culture conditions in R&D is becoming ever more important. Especially in the stem cell field, there is a need to design tuneable cell culture surfaces. For example, labs that routinely culture embryonic stem cells demand non-fouling and non-adsorbing surfaces to ensure proper cell growth.

LipoCoat© coatings offers the possibility of being engineered to display and include different proteins and other bio-actives to impart a specific bioactivity, rather than being a (bio)inert surface. For example, if you wanted to activate other cells such as stem cells or immune cells, detect certain proteins or to encourage tailored cell adhesion or even capture molecules LipoCoat© coatings can be used. A common problem in drug screening applications is drug adsorption to the wells plates which causes compound loss and makes the screenings less reliable. Therefore, non-fouling and non-adherent are equally important for stem cell and drug screening applications6.

Our technology enables the design and preparation of bio-active surfaces through supramolecular or chemical modification. Therefore low background, cell-compatible surfaces and, if so desired, spatiotemporal incorporation of biochemical cues are accessible, improving or enabling new types of analysis.

Permanent implants
The LipoCoat coating platform can be adapted to display a wide-range of bio-active compounds. These can provide additional surface properties to trigger specific biological processes in vivo or in vitro. Osseointegration improvement using LipoCoat coatings on orthopedic implants are under investigation.

Therapeutic coatings
At LipoCoat, one of our future goals is to use our coatings in therapeutic areas. We want to use our technology in the field of tissue engineering, immune responses and controlled drug release.